New studies link between the success of transplant surgery and Circadian Clock
New researches is now releasing a new factors that must be checked in the list of factors required for transplantation surgery beside blood, tissue type and organ size. This factor is the circadian clock.
Previous studies talked about the importance of the time when the surgery is performed stating that it can affect the result of this surgery, while this study is the first of its kind to link between transplantation success and circadian clocks, this study was tested on mice with dysfunctional internal clocks.
The study implemented on mice by the GHSU researchers showed that the arteries of mice with circadian clock dysfunction usually change in their thickness and became thicker and also becoming diseased just weeks after the transplant surgery is implemented on these mice when they were healthy, however, the arteries which has transplanted from healthy mice remain healthy.
Researchers said that the blood vessel diseases are important in the transplant, as you must know the condition of the donor and the time you take the organ to transplant out of the human, since it may not come to mind that he is having a bad clock that may certainly lead to organ failure and rejection that’s why it’s really important to do the transplantation during the best time for the organ.
For Circadian Clock to be chosen in best time, doctors must know that its impact is not only on sleeping, however, it affects not only the brain but also all other parts of the body, due to this researches now can check the circadian clock through blood vessel to be sure about it.
In the time researcher could know about expression of gene in their studies but in humans there is no way to find it out this way but they can only determine it by monitoring the donor for signs of dysfunction such as a sleep disorder or even aberrant behaviors that can impair healthy clocks, such as shift work, but researches will start to discover new ways.
Also these studies showed that the clock can be affected by other factors other than sleeping like eating high fats and also having certain diseases, as a study released in 2009 showed that mice with mutated or missing clock genes has more risk of developing vascular disease just as people who have blood pressure problems and smokers.
Tags: Circadian Clock, studies, transplant surgery